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O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

BACKGROUND: CpG methylation in the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tiss...

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Bibliografiske detaljer
Udgivet i:BBA Clin
Main Authors: Bobola, Michael S., Alnoor, Mohammad, Chen, John Y.-S., Kolstoe, Douglas D., Silbergeld, Daniel L., Rostomily, Robert C., Blank, A., Chamberlain, Marc C., Silber, John R.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280839/
https://ncbi.nlm.nih.gov/pubmed/25558448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbacli.2014.11.003
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