O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

BACKGROUND: CpG methylation in the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tiss...

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Pubblicato in:BBA Clin
Autori principali: Bobola, Michael S., Alnoor, Mohammad, Chen, John Y.-S., Kolstoe, Douglas D., Silbergeld, Daniel L., Rostomily, Robert C., Blank, A., Chamberlain, Marc C., Silber, John R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280839/
https://ncbi.nlm.nih.gov/pubmed/25558448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbacli.2014.11.003
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