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O(6)-Methylguanine-DNA methyltransferase deficiency in developing brain: Implications for brain tumorigenesis
The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is a cardinal defense against the mutagenic and carcinogenic effects of alkylating agents. We have reported evidence that absence of detectable MGMT activity (MGMT(−) phenotype) in human brain is a predisposing factor for primary...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692685/ https://ncbi.nlm.nih.gov/pubmed/17500046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.03.009 |
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