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Survival and tumorigenesis in O(6)-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure
O(6)-methylguanine DNA methyltransferase (MGMT) deficiency is associated with an increased susceptibility to alkylating agent toxicity. To understand the contribution of MGMT in protecting against cyclophosphamide (CP)-induced toxicity, mutagenesis and tumorigenesis, we compared the biological effec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527341/ https://ncbi.nlm.nih.gov/pubmed/18477655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gen018 |
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