Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

Methylating agents are widely distributed environmental carcinogens. Moreover, they are being used in cancer chemotherapy. The primary target of methylating agents is DNA, and therefore, DNA repair is the first-line barrier in defense against their toxic and carcinogenic effects. Methylating agents...

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Bibliografische gegevens
Hoofdauteurs: Wirtz, Stefan, Nagel, Georg, Eshkind, Leonid, Neurath, Markus F., Samson, Leona D., Kaina, Bernd
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2010
Onderwerpen:
Carcinogenesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994278/
https://ncbi.nlm.nih.gov/pubmed/20732909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq174
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