Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

Methylating agents are widely distributed environmental carcinogens. Moreover, they are being used in cancer chemotherapy. The primary target of methylating agents is DNA, and therefore, DNA repair is the first-line barrier in defense against their toxic and carcinogenic effects. Methylating agents...

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Autores principales: Wirtz, Stefan, Nagel, Georg, Eshkind, Leonid, Neurath, Markus F., Samson, Leona D., Kaina, Bernd
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Carcinogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994278/
https://ncbi.nlm.nih.gov/pubmed/20732909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq174
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