Methylation pattern of the O(6)-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis

O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within MGMT promoter leads to loss of its protein expression, and if MGMT methylation correl...

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Bibliografiset tiedot
Päätekijät: Nagasaka, Takeshi, Goel, Ajay, Notohara, Kenji, Takahata, Takaomi, Sasamoto, Hiromi, Uchida, Takuyuki, Nishida, Naoshi, Tanaka, Noriaki, Boland, Clement Richard, Matsubara, Nagahide
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851179/
https://ncbi.nlm.nih.gov/pubmed/18240147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23398
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