Methylation pattern of the O(6)-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis

O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within MGMT promoter leads to loss of its protein expression, and if MGMT methylation correl...

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Main Authors: Nagasaka, Takeshi, Goel, Ajay, Notohara, Kenji, Takahata, Takaomi, Sasamoto, Hiromi, Uchida, Takuyuki, Nishida, Naoshi, Tanaka, Noriaki, Boland, Clement Richard, Matsubara, Nagahide
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851179/
https://ncbi.nlm.nih.gov/pubmed/18240147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23398
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