Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer

BACKGROUND: Colorectal cancers (CRCs) with the CpG island methylator phenotype (CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the BRAF gene. However, the current CIMP criteria are ambiguous, and often result in an underestimation of CIMP frequencies in CRCs....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Nagasaka, Takeshi, Koi, Minoru, Kloor, Matthias, Gebert, Johannes, Vilkin, Alex, Nishida, Naoshi, Shin, Sung Kwan, Sasamoto, Hiromi, Tanaka, Noriaki, Matsubara, Nagahide, Boland, C. Richard, Goel, Ajay
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543132/
https://ncbi.nlm.nih.gov/pubmed/18435933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.02.094
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים