Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer

BACKGROUND: Colorectal cancers (CRCs) with the CpG island methylator phenotype (CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the BRAF gene. However, the current CIMP criteria are ambiguous, and often result in an underestimation of CIMP frequencies in CRCs....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nagasaka, Takeshi, Koi, Minoru, Kloor, Matthias, Gebert, Johannes, Vilkin, Alex, Nishida, Naoshi, Shin, Sung Kwan, Sasamoto, Hiromi, Tanaka, Noriaki, Matsubara, Nagahide, Boland, C. Richard, Goel, Ajay
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543132/
https://ncbi.nlm.nih.gov/pubmed/18435933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.02.094
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