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Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers
Heritable germline epimutations in MSH2 have been reported in a small number of Lynch Syndrome families which lacked germline mutations in the MSH2 gene. It is not known whether somatic MSH2 methylation occurs in MSH2 mutation-positive Lynch Syndrome subjects or sporadic colorectal cancers (CRCs). T...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856102/ https://ncbi.nlm.nih.gov/pubmed/20388775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3290 |
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