MSH6 and MUTYH Deficiency Is a Frequent Event in Early-Onset Colorectal Cancer

PURPOSE: Early-onset colorectal cancer (CRC) is suggestive of a hereditary predisposition. Lynch syndrome is the most frequent CRC hereditary cause. The MUTYH gene has also been related to hereditary CRC. A systematic characterization of these two diseases has not been reported previously in this po...

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Detalhes bibliográficos
Main Authors: Giráldez, María Dolores, Balaguer, Francesc, Bujanda, Luis, Cuatrecasas, Miriam, Muñoz, Jenifer, Alonso-Espinaco, Virginia, Larzabal, Mikel, Petit, Anna, Gonzalo, Victoria, Ocaña, Teresa, Moreira, Leticia, Enríquez-Navascués, José María, Boland, C. Richard, Goel, Ajay, Castells, Antoni, Castellví-Bel, Sergi
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032288/
https://ncbi.nlm.nih.gov/pubmed/20924129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1491
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