Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.

Exposure to exogenous alkylating agents, particularly N-nitroso compounds, has been associated with increased incidence of primary human brain tumors, while intrinsic risk factors are currently unknown. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major defense against t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Silber, J R, Blank, A, Bobola, M S, Mueller, B A, Kolstoe, D D, Ojemann, G A, Berger, M S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38913/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692923/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.6941
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