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Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

Due largely to the inability to accurately quantify and characterize de novo deletion events, the mechanisms underpinning the pathogenic expansion of mtDNA deletions in aging and neuromuscular disorders remain poorly understood. Here, we outline and validate a new tool termed ‘Digital Deletion Detec...

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Detalhes bibliográficos
Main Authors: Taylor, Sean D, Ericson, Nolan G, Burton, Joshua N, Prolla, Tomas A, Silber, John R, Shendure, Jay, Bielas, Jason H
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068027/
https://ncbi.nlm.nih.gov/pubmed/23911137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12146
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