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Mitochondrial DNA exhibits resistance to induced point and deletion mutations

The accumulation of somatic mitochondrial DNA (mtDNA) mutations contributes to the pathogenesis of human disease. Currently, mitochondrial mutations are largely considered results of inaccurate processing of its heavily damaged genome. However, mainly from a lack of methods to monitor mtDNA mutation...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Valente, William J., Ericson, Nolan G., Long, Alexandra S., White, Paul A., Marchetti, Francesco, Bielas, Jason H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062989/
https://ncbi.nlm.nih.gov/pubmed/27550180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw716
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