Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice

Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator mice (Polg(mu...

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Foilsithe in:Exp Gerontol
Main Authors: Kim, Mi-Jung, Haroon, Suraiya, Chen, Guang-Di, Ding, Dalian, Wanagat, Jonathan, Liu, Lijie, Zhang, Yanping, White, Karessa, Park, Hyo-Jin, Han, Chul, Boyd, Kevin, Caicedo, Isabela, Evans, Kaitlyn, Linser, Paul J., Tanokura, Masaru, Prolla, Tomas, Salvi, Richard, Vermulst, Marc, Someya, Shinichi
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857812/
https://ncbi.nlm.nih.gov/pubmed/31344454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2019.110675
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