Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian aging and is the most common sensory disorder in the elderly population. The molecular mechanisms underlying AHL are unknown, and currently there is no treatment for the disorder. Here we report that C57BL/6J m...

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Detalhes bibliográficos
Main Authors: Someya, Shinichi, Xu, Jinze, Kondo, Kenji, Ding, Dalian, Salvi, Richard J., Yamasoba, Tatsuya, Rabinovitch, Peter S., Weindruch, Richard, Leeuwenburgh, Christiaan, Tanokura, Masaru, Prolla, Tomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780799/
https://ncbi.nlm.nih.gov/pubmed/19901338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908786106
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