Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-related Hearing Loss under Caloric Restriction

Caloric restriction (CR) extends the lifespan and healthspan of a variety of species, and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress. Here we report that CR reduces oxidative DNA damage in multiple tissues and prevents AHL...

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Autors principals: Someya, Shinichi, Yu, Wei, Hallows, William C., Xu, Jinze, Vann, James M., Leeuwenburgh, Christiaan, Tanokura, Masaru, Denu, John M., Prolla, Tomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018849/
https://ncbi.nlm.nih.gov/pubmed/21094524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.10.002
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