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Roles of Bak and Sirt3 in paraquat-induced cochlear hair cell damage

Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak, a pro-apoptotic gene, would reduce paraquat ototoxicity or if deletion of Sirt3, which delays age-related hearing loss under caloric restriction, w...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neurotox Res
Main Authors: Ding, Dalian, Prolla, Tomas, Someya, Shinichi, Manohar, Senthilvelan, Salvi, Richard
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277768/
https://ncbi.nlm.nih.gov/pubmed/33900547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-021-00366-6
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