PGC-1α in aging and anti-aging interventions

Por Anderson, Rozalyn, Prolla, Tomas
Publicado em 2009

Mitochondrial oxidative damage and apoptosis in age-related hearing loss

Por Someya, Shinichi, Prolla, Tomas A.
Publicado em 2010

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

Por Kayo, Tsuyoshi, Allison, David B., Weindruch, Richard, Prolla, Tomas A.
Publicado em 2001

The Role of Mitochondrial DNA Mutations in Mammalian Aging

Por Kujoth, Gregory C, Bradshaw, Patrick C, Haroon, Suraiya, Prolla, Tomas A
Publicado em 2007

Effects of Caloric Restriction on Age-Related Hearing Loss in Rodents and Rhesus Monkeys

Por Someya, Shinichi, Tanokura, Masaru, Weindruch, Richard, Prolla, Tomas A., Yamasoba, Tatsuya
Publicado em 2010

Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

Por Dillon, Lloye M., Hida, Aline, Garcia, Sofia, Prolla, Tomas A., Moraes, Carlos T.
Publicado em 2012

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

Por Lee, Cheol-Koo, Allison, David B., Brand, Jaap, Weindruch, Richard, Prolla, Tomas A.
Publicado em 2002

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Por Fox, Raymond G., Magness, Scott, Kujoth, Gregory C., Prolla, Tomas A., Maeda, Nobuyo
Publicado em 2012

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

Por Kukreja, Lokesh, Kujoth, Gregory C, Prolla, Tomas A, Van Leuven, Fred, Vassar, Robert
Publicado em 2014

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

Por Xu, Jinze, Marzetti, Emanuele, Seo, Arnold Y., Kim, Jae-Sung, Prolla, Tomas A., Leeuwenburgh, Christiaan
Publicado em 2010

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

Por Dai, Ying, Clark, Joanne, Zheng, Kangni, Kujoth, Gregory C., Prolla, Tomas A., Simon, David K.
Publicado no Neurotoxicol Teratol (2014)

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Por Edwards, Michael G, Anderson, Rozalyn M, Yuan, Ming, Kendziorski, Christina M, Weindruch, Richard, Prolla, Tomas A
Publicado em 2007

Gene Expression Profiling of Aging in Multiple Mouse Strains: Identification of Aging Biomarkers and Impact of Dietary Antioxidants

Por Park, Sang-Kyu, Kim, Kyoungmi, Page, Grier P., Allison, David B., Weindruch, Richard, Prolla, Tomas A.
Publicado em 2009

The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase γ

Por Someya, Shinichi, Yamasoba, Tatsuya, Kujoth, Gregory C., Pugh, Thomas D., Weindruch, Richard, Tanokura, Masaru, Prolla, Tomas A.
Publicado em 2007

Differential effect of α- and γ-tocopherol supplementation in age-related transcriptional alterations in heart and brain of B6/C3H F1 mice

Por Park, Sang-Kyu, Page, Grier P., Kim, Kyoungmi, Allison, David B., Meydani, Mohsen, Weindruch, Richard, Prolla, Tomas A.
Publicado em 2008

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

Por Dillon, Lloye M., Williams, Siôn L., Hida, Aline, Peacock, Jacqueline D., Prolla, Tomas A., Lincoln, Joy, Moraes, Carlos T.
Publicado em 2012

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

Por Someya, Shinichi, Kujoth, Gregory C., Kim, Mi-Jung, Hacker, Timothy A., Vermulst, Marc, Weindruch, Richard, Prolla, Tomas A.
Publicado no PLoS One (2017)

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Por Chen, Hsiuchen, Vermulst, Marc, Wang, Yun E., Chomyn, Anne, Prolla, Tomas A., McCaffery, J. Michael, Chan, David C.
Publicado em 2010

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse

Por Barger, Jamie L., Kayo, Tsuyoshi, Pugh, Thomas D., Vann, James A., Power, Ronan, Dawson, Karl, Weindruch, Richard, Prolla, Tomas A.
Publicado em 2011

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

Por Taylor, Sean D, Ericson, Nolan G, Burton, Joshua N, Prolla, Tomas A, Silber, John R, Shendure, Jay, Bielas, Jason H
Publicado em 2014