Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (Polg(D257A/D257A)), harboring a proofreading-deficient version of the mtDNA polymerase gamma (POLG), accumulate mtDNA mutations in multiple t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Someya, Shinichi, Kujoth, Gregory C., Kim, Mi-Jung, Hacker, Timothy A., Vermulst, Marc, Weindruch, Richard, Prolla, Tomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291490/
https://ncbi.nlm.nih.gov/pubmed/28158260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171159
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