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Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice
Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (Polg(D257A/D257A)), harboring a proofreading-deficient version of the mtDNA polymerase gamma (POLG), accumulate mtDNA mutations in multiple t...
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| 發表在: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291490/ https://ncbi.nlm.nih.gov/pubmed/28158260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171159 |
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