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Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice
Mitochondrial DNA (mtDNA) mutations are hypothesized to play a pathogenic role in aging and age-related neurodegenerative diseases such as Parkinson’s disease (PD). In support of this, high levels of somatic mtDNA mutations in “POLG mutator” mice carrying a proofreading-deficient form of mtDNA polym...
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| Publicado no: | Neurotoxicol Teratol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293310/ https://ncbi.nlm.nih.gov/pubmed/25450660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ntt.2014.10.004 |
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