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Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice
The mitochondrial DNA (mtDNA) polymerase γ (POLG) mutator mice provide the first experimental evidence that high levels of somatic mtDNA mutations can be functionally significant. Here we report that older homozygous, but not heterozygous, POLG mice show significant reductions in striatal dopaminerg...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682692/ https://ncbi.nlm.nih.gov/pubmed/23542163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2013.03.006 |
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