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Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Changes in intestinal absorption of nutrients are important aspects of the aging process. To address this issue, we investigated the impact of accelerated mitochondrial DNA mutations on the stem/progenitor cells in the crypts of Lieberkühn in mice homozygous for a mitochondrial DNA polymerase gamma...

詳細記述

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書誌詳細
主要な著者: Fox, Raymond G., Magness, Scott, Kujoth, Gregory C., Prolla, Tomas A., Maeda, Nobuyo
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362078/
https://ncbi.nlm.nih.gov/pubmed/22345551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00402.2011
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