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Mitochondrial DNA polymerase editing mutation, Polg(D257A), reduces the diabetic phenotype of Akita male mice by suppressing appetite
Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain undetermined. With the objective of testing whether increased mtDNA mutations exacerbate the diabetic phenotype, we have compared mice heterozygous for t...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102415/ https://ncbi.nlm.nih.gov/pubmed/21555558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106344108 |
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