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Mitochondrial DNA polymerase editing mutation, Polg(D257A), reduces the diabetic phenotype of Akita male mice by suppressing appetite

Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain undetermined. With the objective of testing whether increased mtDNA mutations exacerbate the diabetic phenotype, we have compared mice heterozygous for t...

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Autors principals: Fox, Raymond, Kim, Hyung-Suk, Reddick, Robert L., Kujoth, Gregory C., Prolla, Tomas A., Tsutsumi, Shuichi, Wada, Youichiro, Smithies, Oliver, Maeda, Nobuyo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102415/
https://ncbi.nlm.nih.gov/pubmed/21555558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106344108
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