Mitochondrial DNA polymerase editing mutation, Polg(D257A), reduces the diabetic phenotype of Akita male mice by suppressing appetite

Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain undetermined. With the objective of testing whether increased mtDNA mutations exacerbate the diabetic phenotype, we have compared mice heterozygous for t...

Full description

Saved in:
Bibliographic Details
Main Authors: Fox, Raymond, Kim, Hyung-Suk, Reddick, Robert L., Kujoth, Gregory C., Prolla, Tomas A., Tsutsumi, Shuichi, Wada, Youichiro, Smithies, Oliver, Maeda, Nobuyo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102415/
https://ncbi.nlm.nih.gov/pubmed/21555558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106344108
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items