Mitochondrial DNA polymerase editing mutation, Polg(D257A), reduces the diabetic phenotype of Akita male mice by suppressing appetite

Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain undetermined. With the objective of testing whether increased mtDNA mutations exacerbate the diabetic phenotype, we have compared mice heterozygous for t...

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Detaylı Bibliyografya
Asıl Yazarlar: Fox, Raymond, Kim, Hyung-Suk, Reddick, Robert L., Kujoth, Gregory C., Prolla, Tomas A., Tsutsumi, Shuichi, Wada, Youichiro, Smithies, Oliver, Maeda, Nobuyo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102415/
https://ncbi.nlm.nih.gov/pubmed/21555558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106344108
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