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Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Changes in intestinal absorption of nutrients are important aspects of the aging process. To address this issue, we investigated the impact of accelerated mitochondrial DNA mutations on the stem/progenitor cells in the crypts of Lieberkühn in mice homozygous for a mitochondrial DNA polymerase gamma...

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Autors principals: Fox, Raymond G., Magness, Scott, Kujoth, Gregory C., Prolla, Tomas A., Maeda, Nobuyo
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362078/
https://ncbi.nlm.nih.gov/pubmed/22345551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00402.2011
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