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Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions
OBJECTIVE: Mutations in nuclear-encoded mitochondrial DNA (mtDNA) polymerase (POLG) are known to cause autosomal dominant chronic progressive external ophthalmoplegia (adCPEO) with accumulation of multiple mtDNA deletions in muscles. However, no animal model with a heterozygous Polg mutation represe...
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| Izdano u: | Ann Clin Transl Neurol |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BlackWell Publishing Ltd
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4265062/ https://ncbi.nlm.nih.gov/pubmed/25540805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.133 |
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