The Role of Mitochondrial DNA Mutations in Mammalian Aging

Por Kujoth, Gregory C, Bradshaw, Patrick C, Haroon, Suraiya, Prolla, Tomas A
Publicado em 2007

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Por Uluç, Kutluay, Miranpuri, Amrendra, Kujoth, Gregory C., Aktüre, Erinç, Başkaya, Mustafa K.
Publicado em 2011

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Por Fox, Raymond G., Magness, Scott, Kujoth, Gregory C., Prolla, Tomas A., Maeda, Nobuyo
Publicado em 2012

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

Por Kukreja, Lokesh, Kujoth, Gregory C, Prolla, Tomas A, Van Leuven, Fred, Vassar, Robert
Publicado em 2014

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

Por Dai, Ying, Clark, Joanne, Zheng, Kangni, Kujoth, Gregory C., Prolla, Tomas A., Simon, David K.
Publicado no Neurotoxicol Teratol (2014)

The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase γ

Por Someya, Shinichi, Yamasoba, Tatsuya, Kujoth, Gregory C., Pugh, Thomas D., Weindruch, Richard, Tanokura, Masaru, Prolla, Tomas A.
Publicado em 2007

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

Por Someya, Shinichi, Kujoth, Gregory C., Kim, Mi-Jung, Hacker, Timothy A., Vermulst, Marc, Weindruch, Richard, Prolla, Tomas A.
Publicado no PLoS One (2017)

Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions

Por Fuke, Satoshi, Kametani, Mizue, Yamada, Kazuyuki, Kasahara, Takaoki, Kubota-Sakashita, Mie, Kujoth, Gregory C, Prolla, Tomas A, Hitoshi, Seiji, Kato, Tadafumi
Publicado no Ann Clin Transl Neurol (2014)

Mitochondrial DNA polymerase editing mutation, Polg(D257A), reduces the diabetic phenotype of Akita male mice by suppressing appetite

Por Fox, Raymond, Kim, Hyung-Suk, Reddick, Robert L., Kujoth, Gregory C., Prolla, Tomas A., Tsutsumi, Shuichi, Wada, Youichiro, Smithies, Oliver, Maeda, Nobuyo
Publicado em 2011

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

Por Joseph, Anna-Maria, Adhihetty, Peter J., Wawrzyniak, Nicholas R., Wohlgemuth, Stephanie E., Picca, Anna, Kujoth, Gregory C., Prolla, Tomas A., Leeuwenburgh, Christiaan
Publicado em 2013

Evaluation of gender differences on mitochondrial bioenergetics and apoptosis in mice

Por Sanz, Alberto, Hiona, Asimina, Kujoth, Gregory C., Seo, Arnold Y., Hofer, Tim, Kouwenhoven, Evelyn, Kalani, Rizwan, Prolla, Tomas A., Barja, Gustavo, Leeuwenburgh., Christiaan
Publicado em 2006

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice

Por Dai, Ying, Kiselak, Tomas, Clark, Joanne, Clore, Elizabeth, Zheng, Kangni, Cheng, Allen, Kujoth, Gregory C., Prolla, Tomas A., Maratos-Flier, Eleftheria, Simon, David K.
Publicado em 2013

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

Por Safdar, Adeel, Bourgeois, Jacqueline M., Ogborn, Daniel I., Little, Jonathan P., Hettinga, Bart P., Akhtar, Mahmood, Thompson, James E., Melov, Simon, Mocellin, Nicholas J., Kujoth, Gregory C., Prolla, Tomas A., Tarnopolsky, Mark A.
Publicado em 2011

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

Por Chen, Michael L., Logan, T. Daniel, Hochberg, Maryann L., Shelat, Suresh G., Yu, Xiang, Wilding, Gregory E., Tan, Wei, Kujoth, Gregory C., Prolla, Tomas A., Selak, Mary A., Kundu, Mondira, Carroll, Martin, Thompson, James E.
Publicado em 2009

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

Por Hiona, Asimina, Sanz, Alberto, Kujoth, Gregory C., Pamplona, Reinald, Seo, Arnold Y., Hofer, Tim, Someya, Shinichi, Miyakawa, Takuya, Nakayama, Chie, Samhan-Arias, Alejandro K., Servais, Stephane, Barger, Jamie L., Portero-Otín, Manuel, Tanokura, Masaru, Prolla, Tomas A., Leeuwenburgh, Christiaan
Publicado em 2010