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Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality control processes in ske...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Joseph, Anna-Maria, Adhihetty, Peter J., Wawrzyniak, Nicholas R., Wohlgemuth, Stephanie E., Picca, Anna, Kujoth, Gregory C., Prolla, Tomas A., Leeuwenburgh, Christiaan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720551/
https://ncbi.nlm.nih.gov/pubmed/23935986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069327
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