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Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality control processes in ske...

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Detalhes bibliográficos
Main Authors: Joseph, Anna-Maria, Adhihetty, Peter J., Wawrzyniak, Nicholas R., Wohlgemuth, Stephanie E., Picca, Anna, Kujoth, Gregory C., Prolla, Tomas A., Leeuwenburgh, Christiaan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720551/
https://ncbi.nlm.nih.gov/pubmed/23935986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069327
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