Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Mitochondria are highly mobile and dynamic organelles that continually fuse and divide. These processes allow mitochondria to exchange contents, including mitochondrial DNA (mtDNA). Here we examine the functions of mitochondrial fusion in differentiated skeletal muscle through conditional deletion o...

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Huvudupphovsmän: Chen, Hsiuchen, Vermulst, Marc, Wang, Yun E., Chomyn, Anne, Prolla, Tomas A., McCaffery, J. Michael, Chan, David C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876819/
https://ncbi.nlm.nih.gov/pubmed/20403324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.02.026
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