The mutation rate of the human mtDNA deletion mtDNA4977.

The human mitochondrial mutation mtDNA4977 is a 4,977-bp deletion that originates between two 13-bp direct repeats. We grew 220 colonies of cells, each from a single human cell. For each colony, we counted the number of cells and amplified the DNA by PCR to test for the presence of a deletion. To es...

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Bibliographic Details
Main Authors: Shenkar, R., Navidi, W., Tavaré, S., Dang, M. H., Chomyn, A., Attardi, G., Cortopassi, G., Arnheim, N.
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1914802/
https://ncbi.nlm.nih.gov/pubmed/8808591
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