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Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging th...

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Bibliographische Detailangaben
Hauptverfasser: Dillon, Lloye M., Hida, Aline, Garcia, Sofia, Prolla, Tomas A., Moraes, Carlos T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433471/
https://ncbi.nlm.nih.gov/pubmed/22962610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044335
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