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Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool

With age, muscle mass and integrity are progressively lost leaving the elderly frail, weak and unable to independently care for themselves. Defined as sarcopenia, this age-related muscle atrophy appears to be multifactorial but its definite cause is still unknown. Mitochondrial dysfunction has been...

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Detalhes bibliográficos
Main Authors: Wang, Xiao, Pickrell, Alicia M., Rossi, Susana G., Pinto, Milena, Dillon, Lloye M., Hida, Aline, Rotundo, Richard L., Moraes, Carlos T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766186/
https://ncbi.nlm.nih.gov/pubmed/23760083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt251
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