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The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers
Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To invest...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175596/ https://ncbi.nlm.nih.gov/pubmed/21109200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.012 |
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