The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers

Polg mtDNA mutator mice are important models for investigating the role of acquired mtDNA mutations in aging. Despite extensive study, there remains little consensus on either the etiology of the progeroid phenotype or the mtDNA mutation spectrum induced by disrupted polymerase-γ function. To invest...

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Hlavní autoři: Williams, Siôn L., Huang, Jia, Edwards, Yvonne J.K., Ulloa, Rick H., Dillon, Lloye M., Prolla, Tomas A., Vance, Jeffery M., Moraes, Carlos T., Züchner, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175596/
https://ncbi.nlm.nih.gov/pubmed/21109200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.012
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