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Somatic mtDNA Mutation Spectra in the Aging Human Putamen

The accumulation of heteroplasmic mitochondrial DNA (mtDNA) deletions and single nucleotide variants (SNVs) is a well-accepted facet of the biology of aging, yet comprehensive mutation spectra have not been described. To address this, we have used next generation sequencing of mtDNA-enriched librari...

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Bibliografske podrobnosti
Main Authors: Williams, Siôn L., Mash, Deborah C., Züchner, Stephan, Moraes, Carlos T.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854840/
https://ncbi.nlm.nih.gov/pubmed/24339796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003990
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