Germline and somatic mtDNA mutations in mouse aging

The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ma, Hong, Lee, Yeonmi, Hayama, Tomonari, Van Dyken, Crystal, Marti-Gutierrez, Nuria, Li, Ying, Ahmed, Riffat, Koski, Amy, Kang, Eunju, Darby, Hayley, Gonmanee, Thanasup, Park, Younjung, Wolf, Don P., Jai Kim, Chong, Mitalipov, Shoukhrat
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057648/
https://ncbi.nlm.nih.gov/pubmed/30040856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201304
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