Germline and somatic mtDNA mutations in mouse aging

The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multi...

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Vydáno v:PLoS One
Hlavní autoři: Ma, Hong, Lee, Yeonmi, Hayama, Tomonari, Van Dyken, Crystal, Marti-Gutierrez, Nuria, Li, Ying, Ahmed, Riffat, Koski, Amy, Kang, Eunju, Darby, Hayley, Gonmanee, Thanasup, Park, Younjung, Wolf, Don P., Jai Kim, Chong, Mitalipov, Shoukhrat
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057648/
https://ncbi.nlm.nih.gov/pubmed/30040856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201304
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