Deleterious mtDNA mutations are common in mature oocytes

Heritable mitochondrial DNA (mtDNA) mutations are common, yet only a few recurring pathogenic mtDNA variants account for the majority of known familial cases in humans. Purifying selection in the female germline is thought to be responsible for the elimination of most harmful mtDNA mutations during...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Ma, Hong, Hayama, Tomonari, Van Dyken, Crystal, Darby, Hayley, Koski, Amy, Lee, Yeonmi, Gutierrez, Nuria Marti, Yamada, Satsuki, Li, Ying, Andrews, Michael, Ahmed, Riffat, Liang, Dan, Gonmanee, Thanasup, Kang, Eunju, Nasser, Mohammed, Kempton, Beth, Brigande, John, McGill, Trevor J, Terzic, Andre, Amato, Paula, Mitalipov, Shoukhrat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068114/
https://ncbi.nlm.nih.gov/pubmed/31621839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioz202
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