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Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice

Hearing gradually declines with age in both animals and humans and this condition is known as age-related hearing loss. Here, we investigated the effects of deficiency of Sirt1, a member of the mammalian sirtuin family, on age-related cochlear pathology and associated hearing loss in C57BL/6 mice, a...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Han, Chul, Linser, Paul, Park, Hyo-Jin, Kim, Mi-Jung, White, Karessa, Vann, James M., Ding, Dalian, Prolla, Tomas A., Someya, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893170/
https://ncbi.nlm.nih.gov/pubmed/27255815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.03.023
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