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Effects of Gsta4 Deficiency on Age-related Cochlear Pathology and Hearing Loss in Mice

The glutathione transferase (GST) detoxification system converts exogenous and endogenous toxins into a less toxic form by conjugating the toxic compound to reduced glutathione (GSH) by a variety of GST enzymes. Of the ~20 GST isoforms, GSTA4 exhibits high catalytic efficiency toward 4-hydroxynonena...

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Detalhes bibliográficos
Publicado no:Exp Gerontol
Main Authors: Park, Hyo-Jin, Kim, Mi-Jung, Han, Chul, White, Karessa, Ding, Dalian, Boyd, Kevin, Salvi, Richard, Someya, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062562/
https://ncbi.nlm.nih.gov/pubmed/32044382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2020.110872
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