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Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O(6)-Benzylguanine to Brain Tumors
[Image: see text] Resistance to temozolomide (TMZ) based chemotherapy in glioblastoma multiforme (GBM) has been attributed to the upregulation of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Inhibition of MGMT using O(6)-benzylguanine (BG) has shown promise in these patien...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2014
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4212796/ https://ncbi.nlm.nih.gov/pubmed/25247850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn503735w |
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