Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O(6)-Benzylguanine to Brain Tumors

[Image: see text] Resistance to temozolomide (TMZ) based chemotherapy in glioblastoma multiforme (GBM) has been attributed to the upregulation of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Inhibition of MGMT using O(6)-benzylguanine (BG) has shown promise in these patien...

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Detalhes bibliográficos
Main Authors: Stephen, Zachary R., Kievit, Forrest M., Veiseh, Omid, Chiarelli, Peter A., Fang, Chen, Wang, Kui, Hatzinger, Shelby J., Ellenbogen, Richard G., Silber, John R., Zhang, Miqin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212796/
https://ncbi.nlm.nih.gov/pubmed/25247850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn503735w
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