Dissecting mammalian immunity through mutation

بواسطة Siggs, Owen M
منشور في 2014

The BTB-ZF transcription factors

بواسطة Siggs, Owen M., Beutler, Bruce
منشور في 2012

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C

بواسطة Siggs, Owen M., Schnabl, Bernd, Webb, Bill, Beutler, Bruce
منشور في 2011

ZBTB1 is a determinant of lymphoid development

بواسطة Siggs, Owen M., Li, Xiaohong, Xia, Yu, Beutler, Bruce
منشور في 2012

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

بواسطة Siggs, Owen M., Grieve, Adam, Xu, Hongmei, Bambrough, Paul, Christova, Yonka, Freeman, Matthew
الحاوية / القاعدة Biol Open (2014)

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction

بواسطة Siggs, Owen M, Yates, Adèle L, Schlenner, Susan, Liston, Adrian, Lesage, Sylvie, Goodnow, Christopher C
منشور في 2014

Risk Stratification and Clinical Utility of Polygenic Risk Scores in Ophthalmology

بواسطة Qassim, Ayub, Souzeau, Emmanuelle, Hollitt, Georgie, Hassall, Mark M., Siggs, Owen M., Craig, Jamie E.
الحاوية / القاعدة Transl Vis Sci Technol (2021)

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

بواسطة Siggs, Owen M., Cruite, Justin T., Du, Xin, Rutschmann, Sophie, Masliah, Eliezer, Beutler, Bruce, Oldstone, Michael B. A.
منشور في 2012

iRhom2 is required for the secretion of mouse TNFα

بواسطة Siggs, Owen M., Xiao, Nengming, Wang, Ying, Shi, Hexin, Tomisato, Wataru, Li, Xiaohong, Xia, Yu, Beutler, Bruce
منشور في 2012

Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

بواسطة Schneider, Christoph, Nobs, Samuel P., Heer, Alex K., Hirsch, Emilio, Penninger, Josef, Siggs, Owen M., Kopf, Manfred
الحاوية / القاعدة J Leukoc Biol (2016)

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

بواسطة Siggs, Owen M., Arnold, Carrie N., Huber, Christoph, Pirie, Elaine, Xia, Yu, Lin, Pei, Nemazee, David, Beutler, Bruce
منشور في 2011

Quantitative reduction of the T cell receptor adapter protein SLP-76 unbalances immunity and immune regulation

بواسطة Siggs, Owen M., Miosge, Lisa A., Daley, Stephen R., Asquith, Kelly, Foster, Paul S., Liston, Adrian, Goodnow, Christopher C.
الحاوية / القاعدة J Immunol (2015)

Autosomal dominant nanophthalmos and high hyperopia associated with a C-terminal frameshift variant in MYRF

بواسطة Siggs, Owen M., Souzeau, Emmanuelle, Breen, James, Qassim, Ayub, Zhou, Tiger, Dubowsky, Andrew, Ruddle, Jonathan B., Craig, Jamie E.
الحاوية / القاعدة Mol Vis (2019)

Opposing functions of Zap70 for immunity and tolerance titrate differentially in response to inherited single nucleotide substitutions

بواسطة Siggs, Owen M, Miosge, Lisa A, Yates, Adèle L, Kucharska, Edyta M, Sheahan, Daniel, Brdicka, Tomas, Weiss, Arthur, Liston, Adrian, Goodnow, Christopher C
منشور في 2007

Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif

بواسطة Siggs, Owen M., Russell, Amanda, Singh-Grewal, Davinder, Wong, Melanie, Chan, Pearl, Craig, Maria E., O'Loughlin, Ted, Stormon, Michael, Goodnow, Christopher C.
الحاوية / القاعدة Front Immunol (2019)

Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation

بواسطة Won, Sungyong, Eidenschenk, Celine, Arnold, Carrie N., Siggs, Owen M., Sun, Lei, Brandl, Katharina, Mullen, Tina-Marie, Nemerow, Glen R., Moresco, Eva Marie Y., Beutler, Bruce
منشور في 2012

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

بواسطة Arnold, Carrie N., Pirie, Elaine, Dosenovic, Pia, McInerney, Gerald M., Xia, Yu, Wang, Nathaniel, Li, Xiaohong, Siggs, Owen M., Karlsson Hedestam, Gunilla B., Beutler, Bruce
منشور في 2012

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

بواسطة Brandl, Katharina, Sun, Lei, Neppl, Christina, Siggs, Owen M., Le Gall, Sylvain M., Tomisato, Wataru, Li, Xiaohong, Du, Xin, Maennel, Daniela N., Blobel, Carl P., Beutler, Bruce
منشور في 2010

Partial duplication of the CRYBB1-CRYBA4 locus is associated with autosomal dominant congenital cataract

بواسطة Siggs, Owen M, Javadiyan, Shari, Sharma, Shiwani, Souzeau, Emmanuelle, Lower, Karen M, Taranath, Deepa A, Black, Jo, Pater, John, Willoughby, John G, Burdon, Kathryn P, Craig, Jamie E
الحاوية / القاعدة Eur J Hum Genet (2017)

Gene‐specific facial dysmorphism in Axenfeld‐Rieger syndrome caused by FOXC1 and PITX2 variants

بواسطة Souzeau, Emmanuelle, Siggs, Owen M., Pasutto, Francesca, Knight, Lachlan S. W., Perez‐Jurado, Luis A., McGregor, Lesley, Le Blanc, Shannon, Barnett, Christopher P., Liebelt, Jan, Craig, Jamie E.
الحاوية / القاعدة Am J Med Genet A (2020)