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iRhom2 is required for the secretion of mouse TNFα
TNFα is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFα secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382936/ https://ncbi.nlm.nih.gov/pubmed/22550345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-417949 |
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