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iRhom2 is required for the secretion of mouse TNFα

TNFα is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFα secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages...

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Detalhes bibliográficos
Main Authors: Siggs, Owen M., Xiao, Nengming, Wang, Ying, Shi, Hexin, Tomisato, Wataru, Li, Xiaohong, Xia, Yu, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382936/
https://ncbi.nlm.nih.gov/pubmed/22550345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-417949
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