iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

Lupus nephritis (LN) often results in progressive renal dysfunction. The inactive rhomboid 2 (iRhom2) is a newly identified key regulator of A disintegrin and metalloprotease 17 (ADAM17), whose substrates, such as TNF-α and heparin-binding EGF (HB-EGF), have been implicated in the pathogenesis of ch...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Qing, Xiaoping, Chinenov, Yurii, Redecha, Patricia, Madaio, Michael, Roelofs, Joris J.T.H., Farber, Gregory, Issuree, Priya D., Donlin, Laura, Mcllwain, David R., Mak, Tak W., Blobel, Carl P., Salmon, Jane E.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873859/
https://ncbi.nlm.nih.gov/pubmed/29369823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97650
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