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iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane tether. The trafficking of TACE to the cell surfa...
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| Publicat a: | eLife |
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| Autors principals: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6042963/ https://ncbi.nlm.nih.gov/pubmed/29897333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35032 |
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