Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

Loss of iRhom2, a catalytically inactive rhomboid-like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2-null mice appear normal: they do not show the several defects...

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Bibliografiska uppgifter
Huvudupphovsmän: Christova, Yonka, Adrain, Colin, Bambrough, Paul, Ibrahim, Ashraf, Freeman, Matthew
Materialtyp: Artigo
Språk:Inglês
Publicerad: European Molecular Biology Organization 2013
Ämnen:
Scientific Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807218/
https://ncbi.nlm.nih.gov/pubmed/23969955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.128
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