Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor recepto...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Grieve, Adam Graham, Xu, Hongmei, Künzel, Ulrike, Bambrough, Paul, Sieber, Boris, Freeman, Matthew
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436907/
https://ncbi.nlm.nih.gov/pubmed/28432785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23968
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items