iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane tether. The trafficking of TACE to the cell surfa...

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Publicado en:eLife
Autores principales: Oikonomidi, Ioanna, Burbridge, Emma, Cavadas, Miguel, Sullivan, Graeme, Collis, Blanka, Naegele, Heike, Clancy, Danielle, Brezinova, Jana, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Bolado, Alfonso, von Kriegsheim, Alex, Martin, Seamus J, Steinberg, Florian, Strisovsky, Kvido, Adrain, Colin
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042963/
https://ncbi.nlm.nih.gov/pubmed/29897333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35032
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