iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane tether. The trafficking of TACE to the cell surfa...

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Veröffentlicht in:eLife
Hauptverfasser: Oikonomidi, Ioanna, Burbridge, Emma, Cavadas, Miguel, Sullivan, Graeme, Collis, Blanka, Naegele, Heike, Clancy, Danielle, Brezinova, Jana, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Bolado, Alfonso, von Kriegsheim, Alex, Martin, Seamus J, Steinberg, Florian, Strisovsky, Kvido, Adrain, Colin
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042963/
https://ncbi.nlm.nih.gov/pubmed/29897333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35032
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