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iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane tether. The trafficking of TACE to the cell surfa...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6042963/ https://ncbi.nlm.nih.gov/pubmed/29897333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35032 |
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