Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation

The downregulation of translation through eIF2α phosphorylation is a cellular response to diverse stresses, including viral infection, and is mediated by the GCN2 kinase, protein kinase R (PKR), protein kinase-like endoplasmic reticulum kinase (PERK), and heme-regulated inhibitor kinase (HRI). Altho...

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Main Authors: Won, Sungyong, Eidenschenk, Celine, Arnold, Carrie N., Siggs, Owen M., Sun, Lei, Brandl, Katharina, Mullen, Tina-Marie, Nemerow, Glen R., Moresco, Eva Marie Y., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264364/
https://ncbi.nlm.nih.gov/pubmed/22114338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05660-11
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